Loading...
Please wait, while we are loading the content...
Structural differences between HLA-DQ molecules associated with myasthenia gravis characterized by molecular modeling
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hjelmström, Peter Deweese-Scott, Carol Penzotti, Julie E. Lybrand, Terry P. Sanjeevi, Carani B. |
| Copyright Year | 1998 |
| Abstract | Myasthenia gravis (MG) is characterized by muscle weakness due to autoimmunity against the nicotinic acetylcholine receptor (nAChR). MG is associated with polymorphisms in HLA-DQ genes and the aim of the present study was to characterize structural differences in the peptide binding groove of HLA-DQ molecules positively and negatively associated with MG. Three dimensional models of the positively associated DQ2 (DQB1*02) and negatively associated DQ6 (DQB1*0603) molecules were constructed by homology modeling techniques. The differences in peptide binding properties were primarily localized to peptide-anchor pockets P7 and P9, which might be of importance for the binding of disease-associated peptides from the nAChR. |
| Starting Page | 102 |
| Ending Page | 105 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0165-5728(97)00266-X |
| PubMed reference number | 9627003 |
| Journal | Medline |
| Volume Number | 85 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S016557289700266X |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S016557289700266X?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S0165-5728%2897%2900266-X |
| Journal | Journal of Neuroimmunology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
