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The Contribution of Alternative Translation Start Sites to Human Protein Diversity
| Content Provider | Semantic Scholar |
|---|---|
| Author | Kochetov A. V. |
| Copyright Year | 2008 |
| Abstract | Motivation: According to the scanning model, 40S ribosomal subunits can either initiate translation at start AUG codon in a suboptimal context or scanthrough and initiate translation at downstream AUG(s). Functional significance of the usage of alternative translation start sites is still unknown. Results: Sequence organization of translation initiation signal of human mRNAs was analyzed. It was found that a suboptimal context of annotated start codon correlated with a significantly higher frequency of in-frame downstream AUG codons. We compared predicted subcellular localizations of annotated human proteins and their potential N-terminally truncated forms started from the nearest downstream in-frame AUG codons. It was found that the localization of full and N-truncated protein variants was often different: ca. 3.5 % of human genes tested could produce additional proteins with other targeting signals. It is likely that the in-frame downstream AUGs may be frequently utilized to synthesize additional proteins possessing new functional properties and such a translational polymorphism may serve as an important source of cellular and organelle proteomes. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.bionet.nsc.ru/meeting/bgrs_proceedings/papers/2006/BGRS_2006_V1_064.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
