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The role of alternative translation start sites in the generation of human protein diversity

Content Provider	Springer Nature Link
Author	Kochetov, Alex V. Sarai, Akiri Rogozin, Igor B. Shumny, Vladimir K. Kolchav, Nikolay A.
Copyright Year	2005
Abstract	According to the scanning model, 40S ribosomal subunits initiate translation at the first (5′ proximal) AUG codon they encounter. However, if the first AUG is in a suboptimal context, it may not be recognized, and translation can then initiate at downstream AUG(s). In this way, a single RNA can produce several variant products. Earlier experiments suggested that some of these additional protein variants might be functionally important. We have analysed human mRNAs that have AUG triplets in 5′ untranslated regions and mRNAs in which the annotated translational start codon is located in a suboptimal context. It was found that 3% of human mRNAs have the potential to encode N-terminally extended variants of the annotated proteins and 12% could code for N-truncated variants. The predicted subcellular localizations of these protein variants were compared: 31% of the N-extended proteins and 30% of the N-truncated proteins were predicted to localize to subcellular compartments that differed from those targeted by the annotated protein forms. These results suggest that additional AUGs may frequently be exploited for the synthesis of proteins that possess novel functional properties.
Starting Page	491
Ending Page	496
Page Count	6
File Format	PDF
ISSN	16174615
Journal	Molecular and General Genetics MGG
Volume Number	273
Issue Number	6
e-ISSN	16174623
Language	English
Publisher	Springer-Verlag
Publisher Date	2005-06-15
Publisher Place	Berlin/Heidelberg
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Human mRNAs AUG context Subcellular localization Protein polymorphism
Content Type	Text
Resource Type	Article
Subject	Genetics Medicine Molecular Biology

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