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Crosslinking of gelatin-based drug carriers by genipin induces changes in drug kinetic profiles in vitro
| Content Provider | Semantic Scholar |
|---|---|
| Author | Thakur, Goutam Mitra, Analava Rousseau, Dérick Basak, Amit Sarkar, Siddik Pal, Kunal |
| Copyright Year | 2011 |
| Abstract | Hydrogels are extensively studied as carrier matrices for the controlled release of bioactive molecules. The aim of this study was to design gelatin-based hydrogels crosslinked with genipin and study the impact of crosslinking temperature (5, 15 or 25°C) on gel strength, microstructure, cytocompatibility, swelling and drug release. Gels crosslinked at 25°C exhibited the highest Flory–Rehner crosslink density, lowest swelling ratio and the slowest release of indomethacin (Idn, model anti-inflammatory drug). Diffusional exponents (n) indicated non-Fickian swelling kinetics while drug transport was anomalous. Hydrogel biocompatibility, in vitro cell viability, cell cycle experiments with AH-927 and HaCaT cell lines indicated normal cell proliferation without any effect on cell cycle. Overall, these results substantiated the use of genipin-crosslinked hydrogels as a viable carrier matrix for drug release applications. |
| Starting Page | 115 |
| Ending Page | 123 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s10856-010-4185-3 |
| PubMed reference number | 21107660 |
| Journal | Medline |
| Volume Number | 22 |
| Alternate Webpage(s) | http://dspace.nitrkl.ac.in/dspace/bitstream/2080/1386/1/Crosslinking%20of%20gelatin%5B1%5D.pdf |
| Alternate Webpage(s) | https://doi.org/10.1007/s10856-010-4185-3 |
| Journal | Journal of materials science. Materials in medicine |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
