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Similar neutralizing activity in the HIV-1 infected long term non-progressors(LTNPs) and typical progressors(TPs)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Zheng Li, Tian-Yi Li, Jing-Yun Chen, Lili Liu, Yong-Jian Li, Han-Ping Bao, Zuo-Yi Wang, Xiao-Lin Zhuang, Dao-Min Liu, Si-Yang |
| Copyright Year | 2012 |
| Abstract | Neutralizing antibodies are considered to be an important protective parameter used in HIV-1 vaccine evaluation. However, the exact role that neutralizing antibodies plays in controlling the disease progression of HIV-1 infected peoples is still undetermined. In this paper, we compared the protective function of the neutralizing antibody response in the plasma from LTNP and TP against clade B and clade C pseudoviruses. No difference in the neutralizing activities between the plasma from LTNP and TP was found, which was consistent with the most recent reports. In addition, no correlations between the titer or breadth and CD4+ or viral load in HIV-1 infected individuals were found. The protective roles played by neutralizing antibodies in controlling disease progression of HIV-1 infected people need to be considered in a new viewpoint. |
| Starting Page | 165 |
| Ending Page | 171 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/s12250-012-3239-8 |
| PubMed reference number | 22684470 |
| Journal | Medline |
| Volume Number | 27 |
| Alternate Webpage(s) | https://www.virosin.org/fileZGBDX/journal/article/vs/2012/3/PDF/2012-3239.pdf |
| Alternate Webpage(s) | https://doi.org/10.1007/s12250-012-3239-8 |
| Journal | Virologica Sinica |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
