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| Content Provider | Springer Nature Link |
|---|---|
| Author | Wang, Zheng Li, Tian yi Li, Jing yun Chen, Li li Liu, Yong jian Li, Han ping Bao, Zuo yi Wang, Xiao lin Zhuang, Dao min Liu, Si yang Li, Lin |
| Copyright Year | 2012 |
| Abstract | Neutralizing antibodies are considered to be an important protective parameter used in HIV-1 vaccine evaluation. However, the exact role that neutralizing antibodies plays in controlling the disease progression of HIV-1 infected peoples is still undetermined. In this paper, we compared the protective function of the neutralizing antibody response in the plasma from LTNP and TP against clade B and clade C pseudoviruses. No difference in the neutralizing activities between the plasma from LTNP and TP was found, which was consistent with the most recent reports. In addition, no correlations between the titer or breadth and CD$^{4+}$ or viral load in HIV-1 infected individuals were found. The protective roles played by neutralizing antibodies in controlling disease progression of HIV-1 infected people need to be considered in a new viewpoint. |
| Starting Page | 165 |
| Ending Page | 171 |
| Page Count | 7 |
| File Format | |
| ISSN | 16740769 |
| Journal | Virologica Sinica |
| Volume Number | 27 |
| Issue Number | 3 |
| e-ISSN | 1995820X |
| Language | English |
| Publisher | SP Wuhan Institute of Virology, CAS |
| Publisher Date | 2012-06-09 |
| Publisher Place | Heidelberg |
| Access Restriction | Subscribed |
| Subject Keyword | HIV-1 Long term non-progressor (LTNP) Typical progressor (TP) Neutralization activity Microbial Genetics and Genomics Oncology Medical Microbiology Biochemistry Virology Microbiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Virology Immunology Molecular Medicine |
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