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Hedgehogs , fl uorescence imaging and brain development
| Content Provider | Semantic Scholar |
|---|---|
| Author | Scholpp, Steffen |
| Copyright Year | 2007 |
| Abstract | a highly organised adult body in all its complexity? Since the 19th Century, this question has preoccupied developmental biologists such as Karl Ernst von Baer, Ernst Häckel and Gavin de Beer. The formation of cellular compartments and their maintenance by boundaries that emit morphogenetic signals responsible for organising local development has long been recognised as a key feature of insect development. In the early 1990s, Andrew Lumsden was the fi rst to show the existence of such compartments in vertebrates, specifi cally in the hindbrain region (Lumsden and Keynes, 1989). In 2004, I was fortunate to join his laboratory in the MRC Centre for Developmental Neurobiology at King’s College London. Recently, he showed that one of the prominent structural boundaries in the embryonic forebrain, the Zona Limitans Intrathalamica (ZLI), which bisects the forebrain transversely, is not a simple boundary but also an individual compartment in its own right – the only compartment so far detected in the forebrain (Zeltser et al., 2001). Following this observation, we started to elucidate the mechanism leading to the formation of the ZLI and unravelled specifi c organising functions for this structure: it turns out that the ZLI is crucial for the development of the thalamus – the major relay station between the brain and the outside world. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.rms.org.uk/uploads/assets/uploaded/3fb87316-5b26-46be-a1b7a009242c7822.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
