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Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Han, Arnold Newell, Evan William Glanville, Jacob Fernandez-Becker, Nielsen Q. Khosla, Chaitan Chien, Yueh-Hsiu Davis, Mark M. |
| Copyright Year | 2013 |
| Abstract | Celiac disease is an intestinal autoimmune disease driven by dietary gluten and gluten-specific CD4(+) T-cell responses. In celiac patients on a gluten-free diet, exposure to gluten induces the appearance of gluten-specific CD4(+) T cells with gut-homing potential in the peripheral blood. Here we show that gluten exposure also induces the appearance of activated, gut-homing CD8(+) αβ and γδ T cells in the peripheral blood. Single-cell T-cell receptor sequence analysis indicates that both of these cell populations have highly focused T-cell receptor repertoires, indicating that their induction is antigen-driven. These results reveal a previously unappreciated role of antigen in the induction of CD8(+) αβ and γδ T cells in celiac disease and demonstrate a coordinated response by all three of the major types of T cells. More broadly, these responses may parallel adaptive immune responses to viral pathogens and other systemic autoimmune diseases. |
| File Format | PDF HTM / HTML |
| DOI | 10.1073/pnas.1311861110 |
| PubMed reference number | 23878218 |
| Journal | Medline |
| Volume Number | 110 |
| Issue Number | 32 |
| Alternate Webpage(s) | http://www.pnas.org/content/110/32/13073.full.pdf |
| Alternate Webpage(s) | http://www.pnas.org/content/110/32/13073.full.pdf?with-ds=yes |
| Alternate Webpage(s) | https://doi.org/10.1073/pnas.1311861110 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
