NDLI: Vascular permeability and neurotoxicity.

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Vascular permeability and neurotoxicity.

Content Provider	Semantic Scholar
Copyright Year	1978
Abstract	Neurotoxic substances affect the nervous system in a selective manner. One possible basis for this selectivity is blood vessel permeability. In general, the central nervous system and the peripheral nerve trunks have impermeable blood vessels, but in certain parts the capillaries are "leaky," allowing the passage of a plasma filtrate. Intravenously injected protein tracers rapidly reach nerve cells in these regions, with the implication that these nerve cells are also readily accessible to circulating neurotoxic substances. Some examples of neurotoxicity in the central nervous system show a selectivity that could be due to capillary permeability. In experimental methylmercury poisoning, cranial nerve V and sensory dorsal root ganglia, which lie in regions of vascular permeability, are particularly susceptible. A number of drug and chemically induced neuropathies are predominantly sensory, and may be due, directly or indirectly, to the accessibility of neurotoxic substances to sensory neurons. Examination of areas of potential vulnerability to circulating toxic substances may be of value in the experimental testing of substances for neurotoxicity, where pharmacological tests may be negative and clinical symptoms difficult to assess.
Starting Page	107
Ending Page	116
Page Count	10
File Format	PDF HTM / HTML
PubMed reference number	363411
Volume Number	26
Journal	Environmental health perspectives
Language	English
Access Restriction	Open
Subject Keyword	Abducens Nerve Diseases Afferent neuron Blood Vessel Blood capillaries CNS disorder Capillary Permeability Cranial Nerves Ganglia Ganglia, Spinal Hematological Disease Methylmercury Compounds Nervous system structure Neurons Neurotoxicity Syndromes Peripheral Nerves Pharmacology Poisoning Poisons Posterior root of spinal nerve Tracer nervous system disorder substance
Content Type	Text
Resource Type	Article

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