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Tlx-1 and Tlx-3 homeobox gene expression in cranial sensory ganglia and hindbrain of the chick embryo: markers of patterned connectivity.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Logan, Cairine Wingate, Richard J. T. Mckay, I. J. Lumsden, Andrew G. S. |
| Copyright Year | 1998 |
| Abstract | Recent evidence suggests that in vertebrates the formation of distinct neuronal cell types is controlled by specific families of homeodomain transcription factors. Furthermore, the expression domains of a number of these genes correlates with functionally integrated neuronal populations. We have isolated two members of the divergent T-cell leukemia translocation (HOX11/Tlx) homeobox gene family from chick, Tlx-1 and Tlx-3, and show that they are expressed in differentiating neurons of both the peripheral and central nervous systems. In the peripheral nervous system, Tlx-1 and Tlx-3 are expressed in overlapping domains within the placodally derived components of a number of cranial sensory ganglia. Tlx-3, unlike Tlx-1, is also expressed in neural crest-derived dorsal root and sympathetic ganglia. In the CNS, both genes are expressed in longitudinal columns of neurons at specific dorsoventral levels of the hindbrain. Each column has distinct anterior and/or posterior limits that respect inter-rhombomeric boundaries. Tlx-3 is also expressed in D2 and D3 neurons of the spinal cord. Tlx-1 and Tlx-3 expression patterns within the peripheral and central nervous systems suggest that Tlx proteins may be involved not only in the differentiation and/or survival of specific neuronal populations but also in the establishment of neuronal circuitry. Furthermore, by analogy with the LIM genes, Tlx family members potentially define sensory columns early within the developing hindbrain in a combinatorial manner. |
| Starting Page | 90 |
| Ending Page | 93 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.jneurosci.org/content/jneuro/18/14/5389.full.pdf |
| PubMed reference number | 9651221v1 |
| Volume Number | 18 |
| Issue Number | 14 |
| Journal | The Journal of neuroscience : the official journal of the Society for Neuroscience |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Afferent neuron Axon CNS disorder Cell Nucleus Cellular Phone Chick Embryo Chronic Lymphocytic Leukemia Ganglia, Sensory Gene Expression Hematoma, Epidural, Cranial Neural Crest Neural Pathways Nucleus solitarius Peripheral Nervous System Peripheral Nervous System Neoplasms Posterior root of spinal nerve Sensorimotor Cortex Singular Spinal Cord Sympathetic Ganglia TRANSCRIPTION FACTOR Trigeminal Nuclei hindbrain nerve supply |
| Content Type | Text |
| Resource Type | Article |
