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Die Bedeutung von NAADP für die Ca2+-Signalgebung von T-Zellen der Ratte (Rattus norvegicus, Berkenhout, 1769) und ventrikulären Cardiomyozyten der Maus (Mus musculus, Linnaeus, 1758)
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nebel, Merle |
| Copyright Year | 2011 |
| Abstract | 5 was analyzed during electrical stimulation. In the presence of isoprenalin additional Ca 2+ transients were observed, leading to arrhythmogenic contractions. In following experiments these additional Ca 2+ transients were used as a model for arrhythmia in the heart. The proarrhythmic effect of isoprenalin is most probably mediated by protein kinase A. Notably, administration of BZ194 blocked the appearance of additional Ca 2+ transients and demonstrated a participation of NAADP. Further results indicate, that NAADP releases Ca 2+ from lysosomal stores. This might lead to a Ca 2+ overload of the sarcoplasmic reticulum and finally to the appearance of additional Ca 2+ transients. The present work shows that NAADP is not only crucial for activation of T cells, but may also participate in the development of arrhythmic events in cardiomyocytes. Inhibiting NAADPmediated Ca 2+ signaling prevented the activation of autoreactive T cells and reduced the number of additional Ca 2+ transients in ventricular cardiomyocytes. The NAADP signaling pathway is therefore a promising target for pharmacological interventions in the future. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://ediss.sub.uni-hamburg.de/volltexte/2011/5009/pdf/ZusammenfassungNebelMerlel.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
