NDLI: Real-time measurement of particulate matter deposition in the lung.

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Real-time measurement of particulate matter deposition in the lung.

Content Provider	Semantic Scholar
Author	Invernizzi, Giovanni Boffi, Roberto Ruprecht, Ario Alberto Barnes, Peter J. Kharitonov, Sergei A. Paredi, Paolo
Copyright Year	2006
Abstract	Air pollution and cigarette smoke are recognized health risks. A method was developed for the measurement of the deposition fraction (DF) of polydisperse particulate matter (PM) in human airways. Ten normal volunteers [three females, age range 18-67 years, mean age (SD) 43.9 (14)] made single breath exhalations after inhalation to total lung capacity. The exhaled breath was diverted to a multichannel laser diffraction chamber where the particulate profiler measured 0.3 - 1.0-microm particles. DF was inversely related to expiration flow-rate, 0.69 (0.02) at 4 l min-1 and 0.5 (0.01) at 13 l min-1, respectively (p<0.05), and was influenced by the inhalation flow-rate [0.70 (0.02) at 3 l min-1 and 0.59 (0.02) at 13 l min-1, respectively (p<0.05)], while no differences were found between nasal and oral inhalation (0.68 (0.05) versus 0.67 (0.06), p>0.05). Higher breath holding times were associated with elevated DF [0.74 (0.02) at 20 s, and 0.62 (0.05) without breath holding (p<0.01)]. When the expiratory flow was controlled and the breath hold time standardized, DF was reproducible (CV = 4.85%). PM can be measured in the exhaled breath and its DF can be quantified using a portable device. These methods may be useful in studies investigating the health effects of air pollution and tobacco smoke.
Starting Page	871
Ending Page	871
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://ariambiente.it/media/Ricerche/Biomarkers.pdf
PubMed reference number	16760131v1
Volume Number	11
Issue Number	3
Journal	Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
Language	English
Access Restriction	Open
Subject Keyword	Air Pollution Air Sacs Airborne Particulate Matter Breath Tests Cigarette smoke (substance) Expiration, function Inspiration function Particulate (substance) Physiological Sexual Disorders Structure of parenchyma of lung Tobacco smoke
Content Type	Text
Resource Type	Article

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