NDLI: Relationship between neointimal thickness and shear stress after Wallstent implantation in human coronary arteries.

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Relationship between neointimal thickness and shear stress after Wallstent implantation in human coronary arteries.

Content Provider	Semantic Scholar
Author	Krams, Rob Oomen, J. A. Kloet, Jeroen De
Copyright Year	2001
Abstract	BACKGROUND In-stent restenosis by excessive intimal hyperplasia reduces the long-term clinical efficacy of coronary stents. Because shear stress (SS) is related to plaque growth in atherosclerosis, we investigated whether variations in SS distribution are related to variations in neointima formation. METHODS AND RESULTS In 14 patients, at 6-month follow-up after coronary Wallstent implantation, 3D stent and vessel reconstruction was performed with a combined angiographic and intravascular ultrasound technique (ANGUS). The bare stent reconstruction was used to calculate in-stent SS at implantation, applying computational fluid dynamics. The flow was selected to deliver an average SS of 1.5 N/m(2). SS and neointimal thickness (Th) values were obtained with a resolution of 90 degrees in the circumferential and 2.5 mm in the longitudinal direction. For each vessel, the relationship between Th and SS was obtained by linear regression analysis. Averaging the individual slopes and intercepts of the regression lines summarized the overall relationship. Average Th was 0.44+/-0.20 mm. Th was inversely related to SS: Th=(0.59+/-0.24)-(0.08+/-0.10)xSS (mm) (P<0.05). CONCLUSIONS These data show for the first time in vivo that the Th variations in Wallstents at 6-month follow-up are inversely related to the relative SS distribution. These findings support a hemodynamic mechanism underlying in-stent neointimal hyperplasia formation.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/103/13/1740.full.pdf?download=true
PubMed reference number	11282904v1
Volume Number	103
Issue Number	13
Journal	Circulation
Language	English
Access Restriction	Open
Subject Keyword	Arterial system Atherosclerosis Blood Vessel Tissue Circumference Coronary artery Hemodynamics Hydrodynamics Intravascular ultrasound Neointima Patients STENT, CORONARY Stent Device Component Stent, device restenosis shear stress slope
Content Type	Text
Resource Type	Article

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