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Plasma fatty-acid composition and antioxidant capacity in low birth-weight infants fed formula enriched with n-6 and n-3 long-chain polyunsaturated fatty acids from purified phospholipids.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ramírez, María Luisa Garduño Gallardo, Elsa Mora Souto, Antonieta Suárez Weissheimer, Cristiano Gil, Ángel |
| Copyright Year | 2001 |
| Abstract | OBJECTIVE To determine whether a formula containing n-6 and n-3 long-chain polyunsaturated fatty acids (LCP) from purified phospholipids increases the content of 20:4n-6 and 22:6n-3 of plasma lipids and modifies the plasma antioxidant capacity in low-birth-weight infants. STUDY DESIGN Seventeen infants were fed a conventional formula for low birth-weight infants (F), and 17 a formula containing n-6 and n-3 LCP from purified pig-brain phospholipids (LCP-F). Fourteen infants receiving human milk from a human milk bank were used as a reference (HM). Growth index were measured and blood samples were taken at entry and after 15 days and 30 days of feeding. RESULTS In infants fed LCP-F the levels of 22:6n-3 in total plasma lipids and in plasma phospholipids and triglycerides were higher than in infants fed F and closer to the levels of HM group throughout the study. Docosahexaenoic acid concentration in total plasma lipids was 3.46+/-0.19 mg/dl in infants fed LCP-F and 2.08+/-0.20 in infants fed F after 15 days of feeding (P<0.001), and 3.83+/-0.30 and 2.15+/-0.20 in infants fed LCP-F and F respectively, after 30 days of feeding (P<0.001). The concentration of 20:4n-6 in the LCP-F was significantly higher than in the F group at 15 and 30 days of feeding. Plasma antioxidant capacity did not differ significantly between the study groups. CONCLUSION Feeding low birth-weight infants a formula containing LCP phospholipids results in an increase of n-3 and n-6 LCP in plasma towards that of infants fed human milk. |
| Starting Page | 69 |
| Ending Page | 76 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1054/clnu.2000.0163 |
| PubMed reference number | 11161546 |
| Journal | Medline |
| Volume Number | 20 |
| Issue Number | 1 |
| Alternate Webpage(s) | http://hera.ugr.es/doi/14996716.pdf |
| Alternate Webpage(s) | https://doi.org/10.1054/clnu.2000.0163 |
| Journal | Clinical nutrition |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
