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Participação do sistema glutamatérgico do córtex pré-frontal medial ventral na modulação das consequências comportamentais do estresse de nado forçado.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Pereira, Vitor Silva |
| Copyright Year | 2011 |
| Abstract | PEREIRA, V.S. Participation of the glutamatergic system of the ventral medial prefrontal cortex in the modulation of behavioral consequences of forced swimming stress. 2011. 73p. Thesis (Masters) – School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 2011. It is believed that high amounts of glutamate are related to the neurobiology of depression. Recent studies indicate that the amount of cortical glutamate is increased in depressed patients compared to healthy subjects. Among the cortical structures, the ventral medial prefrontal cortex (CPFMv), divided into infralimbic (IL) and prelimbic (PL) has been most often implicated in the development of mental disorders, such as depression. Considering that IL and PL play different roles on the emotional control in response to stress, this study was aimed to evaluate the hypothesis that the activation of glutamate NMDA receptors within the CPFMv, IL and PL, would facilitate the development of forced swimming-induced behavioral responses, an animal model predictive of antidepressants effects. To this end, we investigated the effects induced by the administration in the PL or the IL of LY 235959, an antagonist of NMDA receptors, at three different times, in animals submitted to the forced swimming test. The administration of LY 235959, in the IL or PL, produced antidepressant-like effects, and this effect is sensitive to moment of drug administration in relation to exposure to forced swimming. Thus, the antidepressant-like effect was observed when blocking the NMDA blockade into the PL occurred immediately after swimming or before re-exposure to stress, whereas in the IL, such treatment promoted antidepressant-like effect only when administered before re-exposure to swimming. Therefore, the results suggest that the glutamatergic neurotransmission mediated by NMDA receptors in the CPFMv contributes to the development of behavioral consequences of stress, so that blocking these receptors would facilitate the adaptation to stress and induce antidepressant-like effects. The results also suggest that PL and IL may be similarly involved in modulating these processes. |
| File Format | PDF HTM / HTML |
| DOI | 10.11606/D.17.2011.tde-11082011-132630 |
| Alternate Webpage(s) | https://teses.usp.br/teses/disponiveis/17/17133/tde-11082011-132630/publico/VITOR_DISSERTACAO_USP_biblioteca.pdf |
| Alternate Webpage(s) | https://doi.org/10.11606/D.17.2011.tde-11082011-132630 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
