NDLI: Prognostic value of p 16 INK 4 a gene deletions in pediatric acute lymphoblastic leukemia

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Prognostic value of p 16 INK 4 a gene deletions in pediatric acute lymphoblastic leukemia

Content Provider	Semantic Scholar
Author	Einsiedel, Hagen Graf Taube, Tillmann Hartmann, Reinhard R. K. Eckert, Cornelia Seifert, Georg Wellmann, Sven Henze, Guenter Seeger, Karl Dr.
Copyright Year	2001
Abstract	cord blood), women 25 to 32 years old (young women group), and women more than 75 years old (elderly women). The frequency of skewed X inactivation in polymorphonuclear cells (PMNs) increased with age: in fact, a cleavage ratio of at least 3.0 was found in 3 of 36 cord blood samples, 5 of 30 young women, and 14 of 31 elderly women. The inactivation patterns found in T lymphocytes were significantly related to those observed in PMNs in both young (P , .001) and elderly women (P , .01). Based on the above estimates, the probability that the 4 women in our family simply had age-related skewing would be 8 divided by 10 000 [(5 of 30) 4], while the probability that skewing was familial is 9992 divided by 10 000. Consequently our conclusion had a strong scientific basis. Aivado et al suggest that a comparison of leukocyte XCIP with XCIP from other tissues is needed. To define the best control tissue for the interpretation of X chromosome inactivation patterns in hematopoietic cells, we previously analyzed X chromosome inactivation patterns in different peripheral blood cell populations and in hair bulbs from healthy women belonging to different age groups. 2
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.bloodjournal.org/content/bloodjournal/97/12/4002.full.pdf?sso-checked=true
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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