NDLI: Endovascular brachytherapy combined with portal vein stenting and transarterial chemoembolization improves overall survival of hepatocellular carcinoma patients with main portal vein tumor thrombus

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Endovascular brachytherapy combined with portal vein stenting and transarterial chemoembolization improves overall survival of hepatocellular carcinoma patients with main portal vein tumor thrombus

Content Provider	Semantic Scholar
Author	Yu, Tian-Zhu Zhang, Wen Liu, Qing-Xin Li, Wen-Hui Ma, Jing-Qin Zhang, Zihan Yang, Min-Jie Wang, Jian-Hua Chen, Bing Zeng, Shao-Chong Luo, Jian-Jun Liu, Ling-Xiao Yan, Zhi-Ping
Copyright Year	2017
Abstract	Hepatocellular carcinoma (HCC) patients with main portal vein tumor thrombus have a median survival time of only about 4 months. We therefore compared the safety and efficacy of endovascular brachytherapy (EVBT) and sequential three-dimensional conformal radiotherapy (3-DCRT). From a cohort of 176 patients, we treated 123 with EVBT using iodine-125 seed strands (group A) and the remaining 53 with sequential 3-DCRT (group B). Overall survival, progression free survival and stent patency characteristics were compared between the two groups. Our analysis demonstrated a median survival of 11.7 ± 1.2 months in group A versus 9.5 ± 1.8 months in group B (p = 0.002). The median progression free survival was 5.3 ± 0.7 months in groupA versus 4.4 ± 0.4 months in group B (p = 0.010). The median stent patency period was 10.3 ± 1.1 months in group A versus 8.7 ± 0.7 months in group B (p = 0.003). Therefore, as compared to sequential 3-DCRT, EVBT combined with portal vein stenting and TACE improved overall survival of HCC patients with main portal vein tumor thrombus.
Starting Page	12108
Ending Page	12119
Page Count	12
File Format	PDF HTM / HTML
DOI	10.18632/oncotarget.14520
PubMed reference number	28076848
Journal	Medline
Volume Number	8
Alternate Webpage(s)	http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=14520&path%5B%5D=46332
Alternate Webpage(s)	https://doi.org/10.18632/oncotarget.14520
Journal	Oncotarget
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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