Loading...
Please wait, while we are loading the content...
Similar Documents
Efficacy of three-dimensional conformal radiotherapy combined with transarterial chemoembolization for hepatocellular carcinoma with portal vein tumor thrombus.
| Content Provider | Europe PMC |
|---|---|
| Author | Wu, Fei-Xiang Lu, Hui-Rong Zhu, Shao-Liang Li, Zi-Hui Zou, Ling Bai, Tao Chen, Jie Yang, Tian-Bo Liang, Shi-Xiong |
| Copyright Year | 2016 |
| Abstract | ObjectiveThe current study aimed to evaluate the efficacy and outcomes of three-dimensional conformal radiotherapy (3DCRT) combined with transarterial chemoembolization (TACE) for treating patients with hepatocellular carcinoma involving portal vein tumor thrombus.MethodsBetween January 2000 and December 2013, a total of 182 hepatocellular carcinoma patients with portal vein tumor thrombus were retrospectively analyzed: 68 patients were treated by 3DCRT alone (group A), 74 by TACE alone (group B), and 40 by a combination of 3DCRT + TACE (group C). The overall survival (OS) of the three groups was compared using the Kaplan–Meier method. The independent predictors of survival were identified using multivariate analysis.ResultsThe total effective rate (complete response + partial response) among all patients was 44% (80/182). The objective response rate (complete response + partial response) was higher in group C than in group A or B, but the differences were not significant. OS rates at 1, 2, and 3 years were significantly higher in group C than in group A or B (P<0.05), while OS rates were similar between groups A and B. Multivariate analysis identified serum levels of alpha-fetoprotein <400 ng/mL and the use of 3DCRT + TACE as independent predictors of better OS.ConclusionThese results suggest that combining 3DCRT with TACE may provide better OS than either technique alone in hepatocellular carcinoma patients with portal vein tumor thrombus. |
| Journal | Oncotargets and Therapy |
| Volume Number | 9 |
| PubMed Central reference number | PMC5138039 |
| PubMed reference number | 27942219 |
| e-ISSN | 11786930 |
| DOI | 10.2147/ott.s113161 |
| Language | English |
| Publisher | Dove Medical Press |
| Publisher Date | 2016-12-01 |
| Access Restriction | Open |
| Rights License | The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. © 2016 Wu et al. This work is published and licensed by Dove Medical Press Limited |
| Subject Keyword | hepatocellular carcinoma portal vein tumor thrombus three-dimensional conformal radiotherapy transarterial chemoembolization overall survival |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Oncology |
