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Functional diversity of GABA activated Cl− currents in Purkinje versus granule neurons in rat cerebellar slices
| Content Provider | Semantic Scholar |
|---|---|
| Author | Puia, Giulia Costa, Erminio Vicini, Stefano |
| Copyright Year | 1994 |
| Abstract | In rat cerebellar slices, we compared whole-cell recordings of spontaneous inhibitory postsynaptic currents (sIPSCs) with Cl- currents resulting from pulses of GABA (1 mM, < 2 ms) to outside-out patches from Purkinje and granule neurons. sIPSCs in Purkinje cells decayed with a single fast exponential, as previously reported, whereas in granule cells sIPSC decay was best described by the sum of a fast and a slow exponential curve, with a variable contribution of the slow component to the peak current. GABA pulses to nucleated patches from granule cells elicited Cl- currents with decays similar to sIPSC decays, whereas in patches from Purkinje neurons GABA pulses produced Cl- currents decaying largely with a fast component, but often followed by a slower exponential. GABA concentration steps produced rapidly desensitizing currents in patches from both cerebellar neurons. In distinct cerebellar neurons, specific functional properties of GABAA receptors may relate to the presence of distinct receptor subtypes. |
| Starting Page | 117 |
| Ending Page | 126 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0896-6273(94)90157-0 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0896627394901570 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0896627394901570?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 8292357 |
| Alternate Webpage(s) | https://doi.org/10.1016/0896-6273%2894%2990157-0 |
| Journal | Medline |
| Volume Number | 12 |
| Journal | Neuron |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
