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1P272 大自由度遺伝子発現制御モデルにおける適応応答の協同的 進化 Cooperative Adaptive Responses in Gene Regulatory Networks with Many Degrees of Freedom
| Content Provider | Semantic Scholar |
|---|---|
| Author | Sawai, Satoshi |
| Copyright Year | 2014 |
| Abstract | Cells generally adapt to environmental changes to achieve homeostasis. Although simple mechanisms for adaptation through network motifs consisting of a few genes are well understood, how regulatory networks involving many genes that activate or repress each other can generate adaptive behaviors is unclear. Here, by numerically evolving gene regulatory networks, we obtained a class of genes whose expression dynamics showed adaptation over almost all genes, albeit sometimes partial adaptation, from which we revealed the general logic underlying such adaptive dynamics with many degrees of freedom, which was not reducible to common motifs with a few genes. These results have implications in the significance to the biological homeostasis of systems with many components. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/biophys/53/supplement1-2/53_KJ00009360393/_pdf/-char/en |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
