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In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Liu, Junting Wang, Yabin Qu, Xiaochao Li, Xiangsi Ma, Xiaopeng Han, Runqiang Hu, Zhenhua Chen, Xueli Sun, Dongdong Zhang, Rongqing Chen, Duofang Chen, Dan Chen, Xiaoyuan Liang, Jimin Cao, Feng Tian, Jie |
| Copyright Year | 2010 |
| Abstract | Bioluminescence tomography (BLT) is a new optical molecular imaging modality, which can monitor both physiological and pathological processes by using bioluminescent light-emitting probes in small living animal. Especially, this technology possesses great potential in drug development, early detection, and therapy monitoring in preclinical settings. In the present study, we developed a dual modality BLT prototype system with Micro-computed tomography (MicroCT) registration approach, and improved the quantitative reconstruction algorithm based on adaptive hp finite element method (hp-FEM). Detailed comparisons of source reconstruction between the heterogeneous and homogeneous mouse models were performed. The models include mice with implanted luminescence source and tumor-bearing mice with firefly luciferase report gene. Our data suggest that the reconstruction based on heterogeneous mouse model is more accurate in localization and quantification than the homogeneous mouse model with appropriate optical parameters and that BLT allows super-early tumor detection in vivo based on tomographic reconstruction of heterogeneous mouse model signal. |
| Starting Page | 59 |
| Ending Page | 70 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://see.xidian.edu.cn/faculty/jimliang/backup/docs/2010-Liu%20Junting-OE.pdf |
| PubMed reference number | 20588440v1 |
| Alternate Webpage(s) | https://doi.org/10.1364/OE.18.013102 |
| DOI | 10.1364/oe.18.013102 |
| Journal | Optics express |
| Volume Number | 18 |
| Issue Number | 12 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Balanced ligamentous tension technique (procedure) Bioluminescence test Dual Early Diagnosis Entity Class - imaging modality Genetic Heterogeneity Implants Luciferases Luciferases, Firefly Neoplasms Pathologic Processes Quantitation Tomography, Emission-Computed X-Ray Computed Tomography X-Ray Microtomography algorithm drug development luminescence |
| Content Type | Text |
| Resource Type | Article |
