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Dual modal in vivo imaging using upconversion luminescence and enhanced computed tomography properties.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhang, Guo Qin Liu, Yanlan Yuan, Qinghai Zong, Chenghua Liu, Jianhua Lu, Lehui |
| Copyright Year | 2011 |
| Abstract | In vivo upconversion luminescence (UCL) imaging, exhibiting favorable characteristics such as high photostability, no blinking, sharp emission lines, and long lifetimes, is recognized as the excellent and significant photoluminescence imaging for the future. To develop the imaging system with high visual sensitivity and tissue penetration, the functional molecules with X-ray computed tomography (CT) contrast were grafted onto upconversion nanoparticles to obtain β-NaYF(4):18% Yb(3+),2%Er(3+)@SiO(2)-I/PEG (UCNPs@SiO(2)-I/PEG) nanoprobes. These nanoprobes are water-soluble, have low cytotoxicity, and possess excellent UCL and remarkable CT contrast. Of particular note is that, besides the element iodine, rare earth elements (Y, Yb, and Er) present in the nanoprobes also show CT contrast. Moreover, no background autofluorescence signal is found in in vivo UCL images. We believe that these nanoprobes with dual modal in vivo imaging of UCL and CT can serve as a promising platform for clinical diagnosis or biomedical studies. |
| Starting Page | 102 |
| Ending Page | 111 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.rsc.org/suppdata/nr/c1/c1nr10736d/c1nr10736d.pdf |
| PubMed reference number | 21904751v1 |
| Alternate Webpage(s) | https://doi.org/10.1039/c1nr10736d |
| DOI | 10.1039/c1nr10736d |
| Journal | Nanoscale |
| Volume Number | 3 |
| Issue Number | 10 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | CNS disorder Dual Exhibits as Topic Luminescent Measurements Photoluminescence Polyethylene Glycols Tomography, Emission-Computed X-Ray Computed Tomography luminescence peginterferon alfa-2b |
| Content Type | Text |
| Resource Type | Article |
