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Characterization of a voltage-gated K+ channel that accelerates the rod response to dim light
| Content Provider | Semantic Scholar |
|---|---|
| Author | Beech, David J. Barnes, Sebronette |
| Copyright Year | 1989 |
| Abstract | In this study a K+ current, IKx, in isolated salamander rod photoreceptors was characterized and its role in shaping small photovoltages was examined. IKx is a standing outward current of about 40 pA at -30 mV that deactivates slowly when the cell is hyperpolarized (tau max = 0.25 s). The voltage and time dependence of IKx are similar to that of M-current, but IKx can be distinguished from M-current because it is not suppressed by acetylcholine and is "blocked" by external Ba2+ in a surprising manner: the activation range of IKx is shifted strongly in the positive direction. Using current-clamp recordings and a computer simulation of the photo-response, we show that IKx figures prominently in setting the dark resting potential and accelerates the voltage response to small photocurrents. |
| Starting Page | 573 |
| Ending Page | 581 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0896-6273(89)90267-5 |
| PubMed reference number | 2642011 |
| Journal | Medline |
| Volume Number | 3 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0896627389902675 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0896627389902675?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0896-6273%2889%2990267-5 |
| Journal | Neuron |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
