NDLI: Host factor-targeted hepatitis B virus therapies.

Content Provider	Semantic Scholar
Author	Gehring, Adam J. Bertoletti, Antonio Tavis, John E.
Copyright Year	2014
Abstract	In this review we will focus on host factors known to impact hepatitis B virus (HBV) replication as current or potential targets for therapeutic intervention. Some immunotherapeutic strategies will be discussed because they have the potential to activate interferon-mediated clearance of HBV, but attention will also be paid to host machinery and proteins that silence covalently closed circular DNA, destabilize viral RNA, or disrupt entry and trafficking of HBV virions. Many of these are in the early stages of development, but may represent novel avenues to reduce HBV burden when combined with nucleos(t)ide analogues.
Starting Page	1023
Ending Page	1029
Page Count	7
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.karger.com/Article/Pdf/360938
PubMed reference number	25034483v1
Alternate Webpage(s)	https://doi.org/10.1159/000360938
DOI	10.1159/000360938
Journal	Intervirology
Volume Number	57
Issue Number	3-4
Language	English
Access Restriction	Open
Subject Keyword	Hepatitis B Virus Herpesvirus 1, Cercopithecine RNA Therapeutic procedure Virion viral capsid secondary envelopment
Content Type	Text
Resource Type	Article

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Host factor-targeted hepatitis B virus therapies.