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Clean and one-pot synthesis of 3,4-dihydropyrimidin-2-(1 H )-ones/thione derivatives using maleic acid as an efficient and environmentally benign natural di-functional Brønsted acid catalyst under solvent-free conditions
| Content Provider | Semantic Scholar |
|---|---|
| Author | Maghsoodlou, Malek Taher Heydari, Reza Lashkari, Mojtaba Mohamadpour, Farzaneh |
| Copyright Year | 2017 |
| Abstract | An efficient synthesis of Biginelli-type compounds using maleic acid as an economical di-functional Brønsted acid catalyst in a one-pot, three-component reaction of β-ketoesters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea is reported. The present methodology is an environmental friendly approach to access 3,4-dihydropyrimidin-2(1H)-ones/tiones derivatives. It offers several merits such as good yields, short reaction times, efficient, eco-friendly, solvent-free conditions, materials available, and simple operational procedure with no column chromatographic separation. The products have been characterized by melting points and H NMR spectroscopy. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://nopr.niscair.res.in/bitstream/123456789/40524/1/IJCB%2056B(2)%20160-164.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |