NDLI: Salicylic Acid as a Bio-Based, Natural and Versatile Catalyst for Green, Solvent-Free and One-Pot Biginelli Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one/thione Derivatives

Content Provider	Semantic Scholar
Author	Mohamadpour, Farzaneh Researchers, Young
Copyright Year	2019
Abstract	Abstract. A green synthetic route for eco-safe and solvent-free preparation of biologically active 3,4dihydropyrimidin-2-(1H)-ones/thiones derivatives via one-pot, three-component Biginelli condensation reaction of β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehyde derivatives) and urea or thiourea have been developed using a salicylic acid as a bio-based, natural and versatile catalyst. The notable advantages of this green approach are use of the bio-based, natural, easy-to-handle and readily green catalyst, easy work-up process, absence of hazardous organic solvents, solvent-free conditions with high to excellent yields and short reaction times and one-pot reactions. The products have been characterized by melting points and H NMR spectroscopy.
Starting Page	136
Ending Page	144
Page Count	9
File Format	PDF HTM / HTML
DOI	10.23939/chcht13.02.136
Volume Number	13
Alternate Webpage(s)	http://science2016.lp.edu.ua/sites/default/files/Full_text_of_%20papers/full_text_911.pdf
Alternate Webpage(s)	https://doi.org/10.23939/chcht13.02.136
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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