NDLI: Dopamine D1 and D3 Receptor Polypharmacology in Cocaine Reward and Cocaine Seeking

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Dopamine D1 and D3 Receptor Polypharmacology in Cocaine Reward and Cocaine Seeking

Content Provider	Semantic Scholar
Author	Galaj, Ewa
Copyright Year	2017
Abstract	Advisor: Professor Robert Ranaldi Background: In the search for efficacious pharmacotherapies to treat cocaine addiction much attention has been given to agents targeting D1 or D3 receptors because of the involvement of these receptors in cocaine-related behaviors. D1 and D3 receptor partial agonists and antagonists have been shown to reduce cocaine reward, reinstatement of cocaine seeking and conditioned place preference (CPP) in rodents and non-human primates. However, translation of these encouraging results with selective D1 or D3 receptor agents has been limited due to a number of factors including toxicity, poor pharmacokinetic properties and extrapyramidal and sedative side effects. Purpose: Given the role of D1 and D3 receptors in cocaine-related behaviors and the urgent need for effective anti-cocaine treatments, it is important that we continue to pursue new pharmacological approaches such as the combinations of compounds that have differential functions at multiple dopamine receptors. The aims of this dissertation were to evaluate the effects of the novel strategy of simultaneous treatments with a D3 receptor antagonist (NGB 2904) and D1 receptor partial agonist (SKF 77434) in animal models of drug addiction, including cue-induced reinstatement of cocaine seeking, cocaine conditioned place preference (CPP) and cocaine self-administration in rats.
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://academicworks.cuny.edu/cgi/viewcontent.cgi?article=2874&context=gc_etds
Alternate Webpage(s)	https://www.gc.cuny.edu/CUNY_GC/media/CUNY-Graduate-Center/PDF/Psychology/Abstracts/DISSERTATION-ABSTRACT.pdf
Alternate Webpage(s)	http://academicworks.cuny.edu/cgi/viewcontent.cgi?article=2874&context=gc_etds
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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