NDLI: Polypharmacology of dopamine D1-like receptor antagonists

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Polypharmacology of dopamine D1-like receptor antagonists

Content Provider	Semantic Scholar
Author	Nikolic, Katarina Filipic, Slavica Agbaba, Danica
Copyright Year	2015
Abstract	Drug discovery based on development of selective ligands for a specific target intended to modulate its activity and revert pathophysiological process is now recognized as too simplistic to design effective agent for complex multifactorial diseases, characterized by diverse physiological dysfunctions caused by deregulations of complex networks of proteins. Major challenge in modern drug discovery is to rationally design multitarget drugs able to specifically modulate only a group of desired targets while minimizing interactions with off-targets. Multifactorial cerebral mechanisms implicated in mental (psychiatrics) and neurodegenerative diseases and interactions of the neurotransmitter systems are two main reasons for applying polypharmacology ('multi-target') strategy in drug discovery for these complex brain diseases. In this paper we review polypharmacological profile and potential therapeutic application of dopamine D1-like receptor antagonists.
Starting Page	287
Ending Page	303
Page Count	17
File Format	PDF HTM / HTML
DOI	10.5937/arhfarm1505287N
Volume Number	65
Alternate Webpage(s)	http://www.farmacija.org/dokumenti/Arhiv%20za%20farmaciju%20br%205%202015%20za%20sajt.pdf
Alternate Webpage(s)	http://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2015/0004-19631505287N.pdf
Alternate Webpage(s)	https://doi.org/10.5937/arhfarm1505287N
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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