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Update on angiotensin AT2 receptors
| Content Provider | Scilit |
|---|---|
| Author | Carey, Robert M. |
| Copyright Year | 2016 |
| Description | Journal: Current opinion in nephrology and hypertension To update major new findings and concepts introduced during the past year on the role of angiotensin II (Ang II) subtype 2 receptors (AT2Rs) in the control of blood pressure (BP) and renal function. AT2R activation prevents sodium (Na+) retention and lowers BP in the Ang II infusion model of experimental hypertension and prevents salt-sensitive hypertension in the obese Zucker rat model of obesity and the metabolic syndrome. Ang II metabolite, des-aspartyl1-Ang II (Ang III) is the predominant AT2R agonist in the kidney and possibly also in the vasculature; a novel synthetic Ang III peptide, β-Pro-Ang III, is vasodepressor and lowers BP in conscious spontaneously hypertensive rats (SHR) in the presence of low-level Ang II type 1 receptor (AT1R) blockade. Because nitric oxide (NO) is a product of AT2R activation, a potential feed forward loop, wherein NO increases AT2R transcription, may reinforce AT2R beneficial actions long term. AT2R activation also reduces proteinuria and oxidative stress in glomerulosclerotic kidneys of high salt obese Zucker rats. Studies during the past year have helped clarify the physiological and pathophysiological roles of AT2Rs and have enhanced the promise of AT2R agonists in cardiovascular and renal disease. |
| Related Links | http://europepmc.org/articles/pmc5813479?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813479/pdf |
| Ending Page | 96 |
| Page Count | 6 |
| Starting Page | 91 |
| ISSN | 10624821 |
| e-ISSN | 14736543 |
| DOI | 10.1097/mnh.0000000000000304 |
| Journal | Current opinion in nephrology and hypertension |
| Issue Number | 2 |
| Volume Number | 26 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2016-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Current opinion in nephrology and hypertension Peripheral Vascular Disease Angiotensin Receptors Kidney Protection |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine Nephrology |
