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Lupus nephritis: challenges and progress
| Content Provider | Scilit |
|---|---|
| Author | Davidson, Anne Aranow, Cynthia Mackay, Meggan |
| Copyright Year | 2019 |
| Description | Journal: Current Opinion in Rheumatology The management of lupus nephritis (LN) remains unsatisfactory due to insufficiently effective treatment regimens and the dearth of reliable predictors of disease onset or progression to guide individualized therapeutic decisions. This review summarizes new findings related to LN over the last 18 months and discusses clinical needs that should be considered in order to advance trials of mechanism based therapeutic strategies. Collaborative teams are addressing how to improve disease definitions and are developing predictive models for disease onset, disease response and risk of flare in individual patients. More attention is being paid to clinical trial design. Advanced technologic approaches are allowing the analysis of small amounts of human tissue and urine in unprecedented detail so as to discover new pathogenic mechanisms and identify disease biomarkers. Novel therapies continue to be tested in disease models and include new strategies to protect renal tissue from cell damage and fibrosis. The collaborative efforts of patients, clinical and translational researchers, the pharmaceutical industry and funding sources are needed to advance therapies for LN. Specialized clinical centers can then deliver optimal and more personalized patient care that will improve patient outcomes. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6812494/pdf |
| Ending Page | 688 |
| Page Count | 7 |
| Starting Page | 682 |
| ISSN | 10408711 |
| e-ISSN | 15316963 |
| DOI | 10.1097/bor.0000000000000642 |
| Journal | Current Opinion in Rheumatology |
| Issue Number | 6 |
| Volume Number | 31 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2019-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Current Opinion in Rheumatology Urology and Nephrology Systemic Lupus Erythematosus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Rheumatology |
