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Advances in lupus genetics
| Content Provider | Scilit |
|---|---|
| Author | Niewold, Timothy B. |
| Copyright Year | 2015 |
| Description | Journal: Current Opinion in Rheumatology The field of systemic lupus erythematosus (SLE) genetics has been advancing rapidly in recent years. This review will summarize recent progress. Genome-wide association and follow up studies have greatly expanded the list of associated polymorphisms, and much current work strives to integrate these polymorphisms into immune system biology and the pathogenic mediators involved in the disease. This review covers some current areas of interest, including genetic studies in non-European SLE patient populations, studies of pathogenic immune system subphenotypes such as type I interferon (IFN) and autoantibodies, and a rapidly growing body of work investigating the functional consequences of the genetic polymorphisms associated with SLE. These studies provide a fascinating window into human SLE disease biology. As the work proceeds from genetic association signal to altered human biology, we move closer to tailoring interventions based upon an individual’s genetic substrate. |
| Related Links | http://europepmc.org/articles/pmc4540605?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540605/pdf |
| Ending Page | 447 |
| Page Count | 8 |
| Starting Page | 440 |
| ISSN | 10408711 |
| e-ISSN | 15316963 |
| DOI | 10.1097/bor.0000000000000205 |
| Journal | Current Opinion in Rheumatology |
| Issue Number | 5 |
| Volume Number | 27 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2015-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Current Opinion in Rheumatology Systemic Lupus Erythematosus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Rheumatology |
