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EFFECT OF DOPEXAMINE ON HEPATIC METABOLIC ACTIVITY IN PATIENTS WITH SEPTIC SHOCK
| Content Provider | Scilit |
|---|---|
| Author | Kiefer, Peter Tugtekin, İlyas Wiedeck, Heide Vogt, Josef Wachter, Uli Bracht, Hendrik Geldner, Götz Georgieff, Michael Radermacher, Peter |
| Copyright Year | 2001 |
| Description | Journal: Shock Hepato-splanchnic metabolic activity is seen to be related to regional blood flow and oxygen/substrate availability in patients with sepsis. Catecholamines, which may modulate metabolic activity perse, are common to stabilize hemodynamics. We studied the effect of a dopexamine-induced increase in splanchnic blood flow (Qspl) on regional metabolic rate in 10 patients with septic shock requiring norepinephrine to maintain mean arterial pressure (>60 mmHg). Splanchnic blood flow was determined using the indocyanine-green method with hepatic venous sampling. We determined the hepato-splanchnic lactate, pyruvate, alanine, and glutamine turnover and the lactate/pyruvate and ketone body ratio as well as the endogenous glucose production (EGP) using the stable isotope approach. Qspl increased from 0.86 (0.79-1.15) to 0.96 (0.92-1.33) L/min/m2, not influencing any parameter of metabolic activity. We speculate that this finding is due to altered beta-adrenoreceptor-mediated thermogenic effects due to the interplay of different beta-sympathomimetics at the receptor site. |
| Related Links | http://pdfs.journals.lww.com/shockjournal/2001/15060/EFFECT_OF_DOPEXAMINE_ON_HEPATIC_METABOLIC_ACTIVITY.3.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1506739665419;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzdpGRzmTA0M/Vx2WsqiQOgtZ/7KS6NZmyMqN+vT5g1u+w8/KrnzdzFRhHPP7/veQ7a;hash|H4nwkFRmTkBlasQFPr3apQ== |
| Ending Page | 431 |
| Page Count | 5 |
| Starting Page | 427 |
| ISSN | 15400514 |
| DOI | 10.1097/00024382-200115060-00003 |
| Journal | Shock |
| Issue Number | 6 |
| Volume Number | 15 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2001-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Shock Peripheral Vascular Disease Metabolic Activity |
| Content Type | Text |
| Resource Type | Article |
| Subject | Emergency Medicine Critical Care and Intensive Care Medicine |
