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ADMISSION ANGIOPOIETIN LEVELS IN CHILDREN WITH SEPTIC SHOCK
| Content Provider | Scilit |
|---|---|
| Author | Giuliano, John S. Lahni, Patrick M. Harmon, Kelli Wong, Hector R. Doughty, Lesley A. Carcillo, Joseph A. Zingarelli, Basilia Sukhatme, Vikas P. Parikh, Samir M. Wheeler, Derek S. |
| Copyright Year | 2007 |
| Description | Journal: Shock Angiopoietin (angpt) 1 and angpt-2 are circulating proteins first ascribed opposing roles in embryonic angiogenesis. Both bind the tyrosine kinase with immunoglobulin-like loop and epidermal growth factor homology domains (Tie) 2 receptor on endothelial cells, but angpt-1 is a Tie-2 agonist, whereas angpt-2 antagonizes Tie-2 signaling. In the developed vasculature, angpt-1 protects against vascular leak, whereas angpt-2 promotes increased vascular permeability. Because alterations in vascular permeability are common in septic shock, we obtained plasma from critically ill children within 24 h of diagnosis of the systemic inflammatory response syndrome (SIRS, n = 20), sepsis (n = 20), or septic shock (n = 61), as well as 15 healthy controls. Plasma levels of angpt-1 and angpt-2 were measured via a commercially available enzyme-linked immunosorbent assay. Plasma angpt-2 levels were significantly elevated in children with septic shock when compared with healthy children, as well as critically ill children with either SIRS or sepsis, and circulating angpt-2 levels seemed to correlate with disease severity and outcome. In addition, plasma angpt-1 levels were significantly decreased in critically ill children with septic shock compared with critically ill children with either SIRS or sepsis. Given the contrasting effects of angpt-2 and angpt-1 on the vascular endothelium, these two factors may play an important role in the pathophysiology of septic shock in children, and further studies are warranted. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754128/pdf |
| Ending Page | 654 |
| Page Count | 5 |
| Starting Page | 650 |
| ISSN | 15400514 |
| DOI | 10.1097/shk.0b013e318123867b |
| Journal | Shock |
| Issue Number | 6 |
| Volume Number | 28 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2007-12-01 |
| Access Restriction | Open |
| Subject Keyword | Peripheral Vascular Disease Endothelial Injury |
| Content Type | Text |
| Resource Type | Article |
| Subject | Emergency Medicine Critical Care and Intensive Care Medicine |
