NDLI: Circulating Levels of Tissue Factor Microparticle Procoagulant Activity Are Reduced With Antiretroviral Therapy and Are Associated With Persistent Inflammation and Coagulation Activation Among HIV-Positive Patients

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Circulating Levels of Tissue Factor Microparticle Procoagulant Activity Are Reduced With Antiretroviral Therapy and Are Associated With Persistent Inflammation and Coagulation Activation Among HIV-Positive Patients

Content Provider	Scilit
Author	Baker, Jason V. Hullsiek, Katherine Huppler Bradford, Robert Prosser, Rachel Tracy, Russell P. Key, Nigel S.
Copyright Year	2013
Description	Journal: JAIDS Journal of Acquired Immune Deficiency Syndromes Activation of coagulation pathways may contribute to risk for non–AIDS-related conditions among HIV-positive patients. Tissue factor (TF)–dependent procoagulant activity on circulating microparticles (MP-TF) in the plasma of 163 HIV-positive participants, both untreated and treated, with viral suppression was measured. MP-TF activity was 39% lower among treated versus untreated participants (P < 0.001), which persisted in adjusted models (−36%, P = 0.03). Among treated participants, MP-TF activity correlated modestly with D-dimer (r = 0.24, P = 0.01), von Willebrand factor (r = 0.36, P < 0.001), and interleukin-6 (r = 0.20, P = 0.04) levels. Future research should focus on mechanisms driving residual functional TF activity and whether these alterations have clinical consequences for non–AIDS-defining complications.
Related Links	http://europepmc.org/articles/pmc3683107?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683107/pdf
Ending Page	371
Page Count	5
Starting Page	367
ISSN	15254135
e-ISSN	10779450
DOI	10.1097/qai.0b013e3182910121
Journal	JAIDS Journal of Acquired Immune Deficiency Syndromes
Issue Number	3
Volume Number	63
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2013-07-01
Access Restriction	Open
Subject Keyword	Journal: JAIDS Journal of Acquired Immune Deficiency Syndromes Infectious Diseases Hiv Infection, Tissue Factor Activity, Coagulation, Inflammation, Cardiovascular Disease
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Pharmacology (medical)

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Circulating Levels of Tissue Factor Microparticle Procoagulant Activity are Reduced with Antiretroviral Therapy and are Associated with Persistent Inflammation and Coagulation Activation among HIV Positive Patients

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