NDLI: Elevated Microparticle Tissue Factor Activity Is Associated With Carotid Artery Plaque in HIV-Infected Women

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Elevated Microparticle Tissue Factor Activity Is Associated With Carotid Artery Plaque in HIV-Infected Women

Content Provider	Scilit
Author	Lin, Juan Xue, Xiaonan Anastos, Kathryn Cohen, Mardge H. Gange, Stephen J. Lazar, Jason M. Liu, Chenglong Mack, Wendy J. Tien, Phyllis C. Tilley, Cathy Hodis, Howard N. Landay, Alan L. Tracy, Russell P. Kaplan, Robert C. Hanna, David B.
Copyright Year	2019
Description	Journal: JAIDS Journal of Acquired Immune Deficiency Syndromes Expression of tissue factor (TF) on the surface of activated monocytes may trigger thrombosis, leading to clotting risk, inflammation, and atherosclerosis. TF-positive microparticles (MP-TF) represent a functionally active form of TF that may be promulgated by long-term HIV infection. We hypothesized that greater MP-TF activity is associated with carotid artery plaque in HIV+ women. In a case-control study nested within the Women’s Interagency HIV Study (WIHS), eligible HIV+ participants underwent B-mode carotid artery ultrasound at 2 study visits occurring 7 years apart. Cases were defined by presence of at least 1 carotid artery plaque assessed at either visit. Cases were matched 1:2 to controls who were found not to have carotid artery plaques. Conditional logistic regression estimated the association of MP-TF activity with presence of carotid artery plaque, adjusting for demographic and behavioral characteristics, HIV-related factors, cardiometabolic risk factors, and serum inflammation biomarkers (hsCRP, IL-6, sCD14, sCD163, Gal-3, Gal-3BP). Elevated MP-TF activity (>0.537 pg/mL) was found to be significantly associated with greater odds of plaque (adjusted odds ratio 3.86, 95% CI 1.06-14.07, p=0.04). The association was attenuated after further adjustment for IL-6, but was unaffected by adjustment for other biomarkers including those denoting monocyte activation. Our findings suggest a link among HIV infection, innate immune system perturbation, coagulation, and atherosclerosis.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456393/pdf
Ending Page	43
Page Count	8
Starting Page	36
ISSN	15254135
e-ISSN	10779450
DOI	10.1097/qai.0000000000001988
Journal	JAIDS Journal of Acquired Immune Deficiency Syndromes
Issue Number	1
Volume Number	81
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2019-05-01
Access Restriction	Open
Subject Keyword	Journal: JAIDS Journal of Acquired Immune Deficiency Syndromes Endocrinology and Metabolism Innate Immune Carotid Artery Plaque Mp Tf
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Pharmacology (medical)

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