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Endothelial Nitric Oxide Synthase Inhibits G$ _{12/13}$ and Rho-Kinase Activated by the Angiotensin II Type-1 Receptor

Content Provider	Scilit
Author	Suzuki, Hiroyuki Kimura, Keita Shirai, Heigoro Eguchi, Kunie Higuchi, Sadaharu Hinoki, Akinari Ishimaru, Kazuhiro Brailoiu, Eugen Dhanasekaran, Danny N. Stemmle, Laura N. Fields, Timothy A. Frank, Gerald D. Autieri, Michael V. Eguchi, Satoru
Copyright Year	2009
Description	Journal: Arteriosclerosis, thrombosis, and vascular biology Background— Although, endothelial nitric oxide (NO) synthase (eNOS) is believed to antagonize vascular remodeling induced by the angiotensin II (AngII) type-1 receptor, the exact signaling mechanism remains unclear. Methods and Results— By expressing eNOS to vascular smooth muscle cells (VSMCs) via adenovirus, we investigated a signal transduction mechanism of the eNOS gene transfer in preventing vascular remodeling induced by AngII. We found marked inhibition of AngII-induced Rho/Rho-kinase activation and subsequent VSMC migration by eNOS gene transfer whereas G$ _{q}$ -dependent transactivation of the epidermal growth factor receptor by AngII remains intact. This could be explained by the specific inhibition of G$ _{12/13}$ activation by eNOS-mediated G$ _{12/13}$ phosphorylation. Conclusion— The eNOS/NO cascade specifically targets the Rho/Rho-kinase system via inhibition of G$ _{12/13}$ to prevent vascular migration induced by AngII, representing a novel signal cross-talk in cardiovascular protection by NO.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704976/pdf https://www.ahajournals.org/doi/pdf/10.1161/ATVBAHA.108.181024
Ending Page	224
Page Count	8
Starting Page	217
ISSN	10795642
e-ISSN	15244636
DOI	10.1161/atvbaha.108.181024
Journal	Arteriosclerosis, thrombosis, and vascular biology
Issue Number	2
Volume Number	29
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2009-02-01
Access Restriction	Open
Subject Keyword	Journal: Arteriosclerosis, thrombosis, and vascular biology Peripheral Vascular Disease G Protein Nitric Oxide Synthase Angiotensin Ii Vascular Smooth Muscle
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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