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Gastrointestinal Symptoms Before and After Total Pancreatectomy With Islet Autotransplantation
| Content Provider | Scilit |
|---|---|
| Author | Crosby, Jill Bellin, Melena D. Radosevich, David M. Chinnakotla, Srinath Dunn, Ty B. Pruett, Timothy L. Freeman, Martin L. Beilman, Greg J. Schwarzenberg, Sarah J. |
| Copyright Year | 2015 |
| Description | Journal: Pancreas Objectives In a large cohort of subjects undergoing total pancreatectomy with islet autotransplantation (TPIAT), we assessed the prevalence and duration of gastrointestinal (GI) symptoms before and after the procedure to determine the impact of enzyme adherence on GI symptoms. Methods Three hundred fifty-six preoperative and postoperative questionnaires were collected from 184 subjects between ages of 5 and 66 years who underwent TPIAT between 2008 and 2011 at the University of Minnesota. Questionnaires were analyzed for self-reported frequency and severity of GI symptoms, pancreatic enzyme usage, and glycemic variability index (GVI). Results After surgery, patient-reported steatorrhea increased whereas constipation decreased. Gastrointestinal symptoms interfered with daily activity in 44% to 69% of subjects, before and after surgery, despite high reported enzyme adherence. Postoperatively, more than 79% of subjects reported consistent use of enzymes at all meals. Presence of GI symptoms did not vary with adherence. The GVI of 2 had a 2.8-fold increased odds of steatorrhea (95% confidence interval, 1.1–7.0) compared with GVI of 0. Conclusions Gastrointestinal symptoms were common after TPIAT; ongoing management is needed. Enzyme nonadherence was not a major contributor to diarrhea/steatorrhea in this cohort. Glycemic variability was closely associated with steatorrhea; poor response to enzyme replacement may complicate diabetes management. |
| Related Links | http://europepmc.org/articles/pmc4357567?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4357567/pdf |
| Ending Page | 458 |
| Page Count | 6 |
| Starting Page | 453 |
| ISSN | 08853177 |
| e-ISSN | 15364828 |
| DOI | 10.1097/mpa.0000000000000266 |
| Journal | Pancreas |
| Issue Number | 3 |
| Volume Number | 44 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2015-04-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Pancreas Exocrine Pancreatic Insufficiency Chronic Pancreatitis Cp - Chronic Pancreatitis Pert - Pancreatic Enzyme Replacement Therapy Tpiat - Total Pancreatectomy with Islet Autotransplantation Gi - Gastrointestinal |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hepatology Endocrinology, Diabetes and Metabolism Internal Medicine Endocrinology |
