A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT): POST (Prospective Observational Study of TPIAT)

Content Provider	Scilit
Author	Bellin, Melena D. Abu-El-Haija, Maisam Morgan, Katherine Adams, David Beilman, Gregory J. Chinnakotla, Srinath Conwell, Darwin L. Dunn, Ty Freeman, Martin L. Gardner, Timothy Kirchner, Varvara A. Lara, Luis F. Long-Simpson, Leslie Nathan, Jaimie D. Naziruddin, Bashoo Nyman, John A. Pruett, Timothy L. Schwarzenberg, Sarah J. Singh, Vikesh K. Smith, Kerrington Steel, Jennifer L. Wijkstrom, Martin Witkowski, Piotr Hodges, James S.
Copyright Year	2018
Description	Journal: Pancreatology Total pancreatectomy with islet autotransplantation (TPIAT) is considered for managing chronic pancreatitis in selected patients when medical and endoscopic interventions have not provided adequate relief from debilitating pain. Although more centers are performing TPIAT, we lack large, multi-center studies to guide decisions about selecting candidates for and timing of TPIAT. Multiple centers across the United States (9 to date) performing TPIAT are prospectively enrolling patients undergoing TPIAT for chronic pancreatitis into the Prospective Observational Study of TPIAT (POST), a NIDDK funded study with a goal of accruing 450 TPIAT recipients. Baseline data include participant phenotype, pancreatitis history, and medical/psychological comorbidities from medical records, participant interview, and participant self-report (Medical Outcomes Survey Short Form-12, EQ-5D, andPROMIS inventories for pain interference, depression, and anxiety). Outcome measures are collected to at least 1 year after TPIAT, including the same participant questionnaires, visual analog pain scale, pain interference scores, opioid requirements, insulin requirements, islet graft function, and hemoglobin A1c. Health resource utilization data are collected for a cost-effectiveness analysis. Biorepository specimens including urine, serum/plasma, genetic material (saliva and blood), and pancreas tissue are collected for future study. This ongoing multicenter research study will enroll and follow TPIAT recipients, aiming to evaluate patient selection and timing for TPIAT to optimize pain relief and quality of life and diabetes outcomes, and to measure the procedure's cost-effectiveness. A biorepository is also established for future ancillary studies.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879010/pdf http://www.pancreatology.net/article/S1424390318300139/pdf
Ending Page	290
Page Count	5
Starting Page	286
ISSN	14243903
e-ISSN	14243911
DOI	10.1016/j.pan.2018.02.001
Journal	Pancreatology
Issue Number	3
Volume Number	18
Language	English
Publisher	Elsevier BV
Publisher Date	2018-04-01
Access Restriction	Open
Subject Keyword	Journal: Pancreatology Total Pancreatectomy
Content Type	Text
Resource Type	Article
Subject	Hepatology Endocrinology, Diabetes and Metabolism Gastroenterology Endocrinology