Loading...
Please wait, while we are loading the content...
Similar Documents
In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants
| Content Provider | Scilit |
|---|---|
| Author | Kidzeru, Elvis B. Hesseling, Anneke C. Passmore, Jo-Ann S. Myer, Landon Gamieldien, Hoyam Tchakoute, Christophe Toukam Gray, Clive M. Sodora, Donald L. Jaspan, Heather B. |
| Copyright Year | 2014 |
| Description | Journal: Aids |
| Abstract | Objective: In sub-Saharan Africa, HIV-exposed uninfected (HEU) infants have higher morbidity and mortality than HIV-unexposed infants. To evaluate whether immune dysfunction contributes to this vulnerability of HEU infants, we conducted a longitudinal, observational cohort study to assess T-cell immune responses to infant vaccines (Mycobacterium bovis BCG and acellular pertussis) and staphylococcal enterotoxin B (SEB). In total, 46 HEU and 46 HIV-unexposed infants were recruited from Khayelitsha, Cape Town. Methods: Vaccine-specific T-cell proliferation (Ki67 expression) and intracellular expression of four cytokines [interferon-γ, interleukin (IL)-2, IL-13 and IL-17] were measured after whole blood stimulation with antigens at 6 and 14 weeks of age. Results: HEU infants demonstrated elevated BCG-specific CD4+ and CD8+ T-cell proliferative responses at 14 weeks (P = 0.041 and 0.002, respectively). These responses were significantly increased even after adjusting for birth weight, feeding mode and gestational age. Similar to BCG, increased CD4+ and CD8+ T-cell proliferation was evident in response to SEB stimulation (P = 0.004 and 0.002, respectively), although pertussis-specific T cells proliferated comparably between the two groups. Within HEU infants, maternal CD4+ cell count and length of antenatal antiretroviral exposure had no effect on T-cell proliferation to BCG or SEB. HIV exposure significantly diminished measurable cytokine polyfunctionality in response to BCG, Bordetella pertussis and SEB stimulation. Conclusion: These data show for the first time, when adjusting for confounders, that exposure to HIV in utero is associated with significant alterations to CD4+ and CD8+T-cell immune responses in infants to vaccines and nonspecific antigens. |
| Related Links | http://europepmc.org/articles/pmc4333196?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333196/pdf |
| Ending Page | 1430 |
| Page Count | 10 |
| Starting Page | 1421 |
| ISSN | 02699370 |
| e-ISSN | 14735571 |
| DOI | 10.1097/qad.0000000000000292 |
| Journal | Aids |
| Issue Number | 10 |
| Volume Number | 28 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2014-06-19 |
| Access Restriction | Open |
| Subject Keyword | Nutrition and Dietetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Immunology and Allergy Immunology |
