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Effects of in Utero Antiretroviral Exposure on Longitudinal Growth of HIV-Exposed Uninfected Infants in Botswana
| Content Provider | Scilit |
|---|---|
| Author | Powis, Kathleen M. Smeaton, Laura Ogwu, Anthony Lockman, Shahin Dryden-Peterson, Scott van Widenfelt, Erik Leidner, Jean Makhema, Joseph Shapiro, Roger L. |
| Copyright Year | 2011 |
| Description | Journal: JAIDS Journal of Acquired Immune Deficiency Syndromes Background: The impact of in utero exposure to highly active antiretroviral therapy (HAART) on longitudinal growth of HIV-uninfected infants is unknown. Methods: The Mashi and Mma Bana PMTCT intervention trials enrolled HIV-infected pregnant women at four sites in Botswana. Breast-fed (BF), HIV-uninfected infants born at 37 weeks or greater were included in this analysis. Weight-for-age (WAZ), length-for-age (LAZ), and weight-for-length (WLZ) z-scores were calculated using World Health Organization Child Growth Standards. Mean z-scores were compared between in utero antiretroviral exposure groups using Student t test, response profiles analysis, and general linear mixed effects modeling. Results: Growth of 619 HAART-exposed and 440 zidovudine-exposed, HIV-uninfected infants was evaluated. Mean birth weights were 3.01 kg for HAART and 3.15 kg for zidovudine-exposed infants (P < 0.001) with lower mean birth WAZ, length-for-age (LAZ), and weight-for-length (WLZ) among HAART-exposed infants (all P < 0.001). HAART-exposed infants had greater improvement in WAZ and weight-for-length (WLZ) from birth through 2 months (P = 0.03, P < 0.001, respectively). The WAZ did not differ between groups from 3 through 6 months (P = 0.26). Length-for-age (LAZ) remained lower in HAART-exposed infants but the incidence of wasting or stunting did not differ between exposure groups. Conclusions: Lower weights in HAART-exposed uninfected infants at birth were rapidly corrected during the first 6 months of life. |
| Related Links | http://europepmc.org/articles/pmc3023002?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3023002/pdf |
| Ending Page | 138 |
| Page Count | 8 |
| Starting Page | 131 |
| ISSN | 15254135 |
| e-ISSN | 10779450 |
| DOI | 10.1097/qai.0b013e3181ffa4f5 |
| Journal | JAIDS Journal of Acquired Immune Deficiency Syndromes |
| Issue Number | 2 |
| Volume Number | 56 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2011-02-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: JAIDS Journal of Acquired Immune Deficiency Syndromes Nutrition and Dietetics Prevention of Mother-to-child Transmission, Hiv, Growth |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Pharmacology (medical) |
