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HEPATIC INJURY AND LIPID PEROXIDATION DURING ISCHEMIA AND REPERFUSION
| Content Provider | Scilit |
|---|---|
| Author | Lee, Sun-Mee Park, Mee-Jung Cho, Tai-Soon Clemens, Mark G. |
| Copyright Year | 2000 |
| Description | Journal: Shock We determined the relationship between lipid peroxidation and alterations in hepatic secretory and microsomal function during various periods of hepatic ischemia/reperfusion. Rats were pretreated with alpha-tocopherol or vehicle and then subjected to 30, 60, and 90 min, no-flow hepatic ischemia in vivo with 1 or 5 h of reperfusion. Serum aminotransferase (ALT) level, wet-dry weight ratio, and lipid peroxidation were increased at 1 and 5 h of reperfusion, and these changes were significantly attenuated by alpha-tocopherol. Na+, K+-ATPase activity, and glucose-6-phosphatase activity were significantly decreased in 90-min ischemic rats, and these decreases were ameliorated by alpha-tocopherol. After 90 min of ischemia, bile flow, cholate output, and bilirubin output were markedly decreased by ischemia/reperfusion, and alpha-tocopherol restored the secretion. Cytochrome P450 content was decreased by ischemia/reperfusion and restored by alpha-tocopherol to the level of that found in the sham-operated group. Aminopyrine N-demethylase activity was decreased, and aniline p-hydroxylase was increased in 60-min ischemic rats. The changes in the activities of the two enzymes were prevented by alpha-tocopherol. Our findings suggest that ischemia/reperfusion diminishes hepatic secretory functions and microsomal drug metabolizing systems in proportion to the duration of ischemia and reperfusion in vivo, and this is associated with increased lipid peroxidation. |
| Related Links | http://pdfs.journals.lww.com/shockjournal/2000/04000/HEPATIC_INJURY_AND_LIPID_PEROXIDATION_DURING.5.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1503842170554;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzdpGRzmTA0M/Vx2WsqiQOgtdu9Z0j9epFtOyvGC/TVD669tBVaThuXR/z84B4GTBFC;hash|CPs7IWvp9rZluvk1fo4aRQ== |
| Ending Page | 284 |
| Page Count | 6 |
| Starting Page | 279 |
| ISSN | 15400514 |
| DOI | 10.1097/00024382-200004000-00005 |
| Journal | Shock |
| Issue Number | 4 |
| Volume Number | 13 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2000-04-01 |
| Access Restriction | Open |
| Subject Keyword | Peripheral Vascular Disease Lipid Peroxidation Ischemia/reperfusion |
| Content Type | Text |
| Resource Type | Article |
| Subject | Emergency Medicine Critical Care and Intensive Care Medicine |
