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$CD4^{+}$ $CD25^{+}$ regulatory cells in acquired MHC tolerance
| Content Provider | Scilit |
|---|---|
| Author | Field, Elizabeth H. Matesic, Damir Rigby, Shawn Fehr, Tricia Rouse, Todd Gao, Quiglan |
| Copyright Year | 2001 |
| Description | Journal: Immunological Reviews Summary: Tolerance to self‐antigens is an ongoing process that begins centrally during T‐cell maturation in the thymus and continues throughout the cell's life in the periphery by a network of regulated restraints. Remaining self‐reactive T‐cells that escape intrathymic deletion may be silenced within the peripheral immune system by specialized regulatory $CD4^{+}$ cells. By analogy, regulatory $CD4^{+}$ cells that control immunity to “acquired self” should arise in circumstances where the immune system acquires tolerance to foreign MHC, such as the tolerance that develops following the exposure to foreign MHC antigens during the neonatal period. We have used this classic model of neonatal tolerance to examine the role of regulatory $CD4^{+}$ cells in acquired tolerance to disparate class I and class II MHC. Adoptive transfer of unfractionated but not $CD4^{+}$‐depleted spleen cells from neonatal tolerant mice into SCID recipients inhibited skin graft rejection by immunocompetent $CD8^{+}$ T cells. Using 5‐bromo‐2′‐deoxyuridine incorporation, standard cytotoxic T‐lymphocyte assays, short‐term interferon‐γ ELISPOT, and intracellular FACS analysis to study $CD8^{+}$ T‐cell effector function, we demonstrated that neonatal tolerant mice contain $CD4^{+}CD25^{+}$ cells that suppress the development of anti‐donor $CD8^{+}$ T‐cell responses in vitro. We conclude that regulatory $CD4^{+}CD25^{+}$ cells initiate and/or maintain tolerance by preventing the development of $CD8^{+}$ T‐cell alloreactivity. |
| Related Links | https://onlinelibrary.wiley.com/doi/pdf/10.1034/j.1600-065X.2001.1820108.x |
| e-ISSN | 1600065X |
| DOI | 10.1034/j.1600-065x.2001.1820108.x |
| Journal | Immunological Reviews |
| Issue Number | 1 |
| Volume Number | 182 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2001-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Immunological Reviews Research and Experimental Medicine Regulatory Cd4 |
| Content Type | Text |
| Resource Type | Article |
