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Phenols as $DiamagneticT_{2}$-Exchange Magnetic Resonance Imaging Contrast Agents
| Content Provider | Scilit |
|---|---|
| Author | Zhang, Jia Li, Yuguo Slania, Stephanie Yadav, Nirbhay N. Liu, Jing Wang, Rongfu Zhang, Jianhua Pomper, Martin G. van Zijl, Peter C. Yang, Xing Liu, Guanshu |
| Copyright Year | 2017 |
| Description | Journal: Chemistry – A European Journal Although $T_{2}$‐exchange $(T_{2ex}$) NMR phenomena have been known for decades, there has been a resurgence of interest to develop $T_{2ex}$ MRI contrast agents. One indispensable advantage of $T_{2ex}$ MR agents is the possibility of using non‐toxic and/or bio‐compatible diamagnetic compounds with intermediate exchangeable protons. Herein a library of phenol‐based compounds is screened and their $T_{2ex}$ contrast (exchange relaxivity, $r_{2ex}$) at 9.4 T determined. The $T_{2ex}$ contrast of phenol protons allows direct detection by MRI at a millimolar concentration level. The effect of chemical modification of the phenol on the $T_{2ex}$ MRI contrast through modulation of exchange rate and chemical shift was also studied and provides a guideline for use of endogenous and exogenous phenols for $T_{2ex}$ MRI contrast. As a proof‐of‐principle application, phenol $T_{2ex}$ contrast can be used to detect enzyme activity in a tyrosinase‐catalyzed catechol oxidation reaction. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786484/pdf |
| Ending Page | 1263 |
| Page Count | 5 |
| Starting Page | 1259 |
| e-ISSN | 15213765 |
| DOI | 10.1002/chem.201705772 |
| Journal | Chemistry – A European Journal |
| Issue Number | 6 |
| Volume Number | 24 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2017-12-19 |
| Access Restriction | Open |
| Subject Keyword | Journal: Chemistry – A European Journal Radiology, Nuclear Medicine and Imaging Magnetic Resonance Imaging |
| Content Type | Text |
| Resource Type | Article |
