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Hexameric $Mn^{II}$Dendrimer as MRI Contrast Agent
| Content Provider | Scilit |
|---|---|
| Author | Zhu, Jiang Gale, Eric M. Atanasova, Iliyana Rietz, Tyson A. Caravan, Peter |
| Copyright Year | 2014 |
| Description | Journal: Chemistry – A European Journal A $Mn^{II}$ chelating dendrimer was prepared as a contrast agent for MRI applications. The dendrimer comprises six tyrosine‐derived [Mn(EDTA)(H_{2}$O)]^{2−}$ moieties coupled to a cyclotriphosphazene core. Variable temperature$ ^{17}$O NMR spectroscopy revealed a single water co‐ligand per $Mn^{II}$ that undergoes fast water exchange (k_{ex}$=(3.0±0.1)×10^{8}$ $s^{−1}$ at 37 °C). The 37 °C per $Mn^{II}$ relaxivity ranged from 8.2 to 3.8 $mM^{−1}$ $s^{−1}$ from 0.47 to 11.7 T, and is sixfold higher on a per molecule basis. From this field dependence a rotational correlation time was estimated as 0.45(±0.02) ns. The imaging and pharmacokinetic properties of the dendrimer were compared to clinically used [Gd(DTPA)(H_{2}$O)]^{2−}$ in mice at 4.7 T. On first pass, the higher per ion relaxivity of the dendrimer resulted in twofold greater blood signal than for [Gd(DTPA)(H_{2}$O)]^{2−}$. Blood clearance was fast and elimination occurred through both the renal and hepatobiliary routes. This $Mn^{II}$ containing dendrimer represents a potential alternative to Gd‐based contrast agents, especially in patients with chronic kidney disease where the use of current Gd‐based agents may be contraindicated. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4260332/pdf |
| Ending Page | 14513 |
| Page Count | 7 |
| Starting Page | 14507 |
| e-ISSN | 15213765 |
| DOI | 10.1002/chem.201403883 |
| Journal | Chemistry – A European Journal |
| Issue Number | 44 |
| Volume Number | 20 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2014-09-15 |
| Access Restriction | Open |
| Subject Keyword | Journal: Chemistry – A European Journal Radiology, Nuclear Medicine and Imaging Imaging Agents Magnetic Resonance Imaging Nmr Spectroscopy |
| Content Type | Text |
| Resource Type | Article |
