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Diagnostic accuracy of fecal immunochemical test in average‐ and familial‐risk colorectal cancer screening
| Content Provider | Scilit |
|---|---|
| Author | Cubiella, Joaquín Castro, Inés Hernandez, Vicent González-Mao, Carmen Rivera, Concepción Iglesias, Felipe Alves, María Teresa Cid, Lucía Soto, Santiago De-Castro, Luisa Vega, Pablo Hermo, Jose Antonio Macenlle, Ramiro Martínez, Alfonso Estevez, Pamela Cid, Estela Herreros-Villanueva, Marta Portillo, Isabel Bujanda, Luis Fernández-Seara, Javier Colonprev |
| Copyright Year | 2014 |
| Description | Journal: United European Gastroenterology Journal There is little information about the fecal immunochemical test (FIT) in familial-risk colorectal cancer (CRC) screening. The objective of this article is to investigate whether FIT diagnostic accuracy for advanced neoplasia (AN) differs between average and familial-risk (first-degree relative) patients. A total of 1317 consecutive participants (595 familial) who collected one stool sample before performing a colonoscopy as a CRC screening test were included. FIT diagnostic accuracy for AN was evaluated with Chi-square test at a 20 µg hemoglobin/g of feces cut-off value. Finally, we determined which variables were independently related to AN. An AN was found in 151 (11.5%) patients. The overall accuracy was not statistically different between both cohorts for AN (88.4%, 91.7%; p = 0.051). At the cut-off stablished, differences in FIT sensitivity (31.1%, 40.6%; p = 0.2) or specificity (96.5%, 97.3%; p = 0.1) were not statistically significant. Finally, independent variables such as sex (male) (odds ratio (OR) 2.1, 95% confidence interval (CI) 1.4-3.1), age (50-65, >65 years) (OR 2.1, 95% CI 1.1-4.3; OR 2.7, 95% CI 1.2-6.1), previous colonoscopy (OR 0.4, 95% CI 0.2-0.9) and FIT ≥20 µg/g feces (OR 17.7, 95% CI 10.8-29.1) were associated with AN diagnosis. FIT accuracy for AN detection is equivalent in average and familial-risk CRC screening cohorts. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245302/pdf |
| Ending Page | 529 |
| Page Count | 8 |
| Starting Page | 522 |
| e-ISSN | 20506414 |
| DOI | 10.1177/2050640614553285 |
| Journal | United European Gastroenterology Journal |
| Issue Number | 6 |
| Volume Number | 2 |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2014-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: United European Gastroenterology Journal Gastroenterology and Hepatology Colorectal Cancer Colorectal Adenoma Colorectal Cancer Screening Familial Colorectal Cancer Fecal Immunochemical Test Sensitivity and Specificity |
| Content Type | Text |
| Resource Type | Article |
