NDLI: Alzheimer mouse brain tissue measured by time resolved fluorescence spectroscopy using single‐ and multi‐photon excitation of label free native molecules

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Alzheimer mouse brain tissue measured by time resolved fluorescence spectroscopy using single‐ and multi‐photon excitation of label free native molecules

Content Provider	Scilit
Author	Das, Bidyut Shi, Lingyan Budansky, Yury Rodriguez‐Contreras, Adrian Alfano, Robert
Copyright Year	2017
Description	Journal: Journal of Biophotonics Time resolved spectroscopic measurements with single-photon and multi-photon excitation of native molecules were performed ex vivo on brain tissues from an Alzheimer's disease (AD) and a wild type (WT) mouse model using a streak camera. The fluorescence decay times of native NADH and FAD show a longer relaxation time in AD than in WT tissue, suggesting less non-radiative processes in AD. The longer emission time of AD may be attributed to the coupling of the key native building block molecules to the amyloid-tau and/or to the caging of the native fluorophores by the deposition of amyloid-beta or tau plaques and neurofibrillary tangles that affect the local non-radiative interactions.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5668196/pdf
e-ISSN	18640648
DOI	10.1002/jbio.201600318
Journal	Journal of Biophotonics
Issue Number	1
Volume Number	11
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2017-05-02
Access Restriction	Open
Subject Keyword	Journal: Journal of Biophotonics Radiology, Nuclear Medicine and Imaging Alzheimer Disease Brain Optics Label Free Molecule Multiphoton Excitation Time Resolved Fluorescence Spectroscopy
Content Type	Text
Resource Type	Article

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