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Regional assessment of in vivo myocardial stiffness using 3D magnetic resonance elastography in a porcine model of myocardial infarction

Content Provider	Scilit
Author	Arunachalam, Shivaram P. Arani, Arvin Baffour, Francis Rysavy, Joseph A. Rossman, Phillip J. Glaser, Kevin J. Lake, David S. Trzasko, Joshua D. Manduca, Armando McGee, Kiaran P. Ehman, Richard L. Araoz, Philip A.
Copyright Year	2017
Description	Journal: Magnetic Resonance in Medicine The stiffness of a myocardial infarct affects the left ventricular pump function and remodeling. Magnetic resonance elastography (MRE) is a noninvasive imaging technique for measuring soft-tissue stiffness in vivo. The purpose of this study was to investigate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE in a porcine model of myocardial infarction, and compare the results with ex vivo uniaxial tensile testing. Myocardial infarct was induced in a porcine model by embolizing the left circumflex artery. Fourteen days postinfarction, MRE imaging was performed in diastole using an echocardiogram-gated spin-echo echo-planar-imaging sequence with 140-Hz vibrations and 3D MRE processing. The MRE stiffness and tensile modulus from uniaxial testing were compared between the remote and infarcted myocardium. Myocardial infarcts showed increased in vivo MRE stiffness compared with remote myocardium (4.6 ± 0.7 kPa versus 3.0 ± 0.6 kPa, P = 0.02) within the same pig. Ex vivo uniaxial mechanical testing confirmed the in vivo MRE results, showing that myocardial infarcts were stiffer than remote myocardium (650 ± 80 kPa versus 110 ± 20 kPa, P = 0.01). These results demonstrate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE. Magn Reson Med 79:361-369, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628104/pdf
Ending Page	369
Page Count	9
Starting Page	361
e-ISSN	15222594
DOI	10.1002/mrm.26695
Journal	Magnetic Resonance in Medicine
Issue Number	1
Volume Number	79
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2017-04-05
Access Restriction	Open
Subject Keyword	Journal: Magnetic Resonance in Medicine Radiology, Nuclear Medicine and Imaging Cardiac Mre Cardiac Elastography Heart Failure Magnetic Resonance Elastography Myocardial Infarction Myocardial Stiffness Shear Modulus
Content Type	Text
Resource Type	Article

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