NDLI: Static and dynamic liver stiffness: An ex vivo porcine liver study using MR elastography

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Static and dynamic liver stiffness: An ex vivo porcine liver study using MR elastography

Content Provider	Scilit
Author	Yang, Chun Yin, Meng Glaser, Kevin J. Zhu, Xiangyang Xu, Kai Ehman, Richard L. Chen, Jun
Copyright Year	2017
Description	Journal: Magnetic resonance imaging Magnetic resonance elastography (MRE) is an MRI-based noninvasive technique for quantitatively assessing tissue stiffness. The hypothesis of this study is that stiffness increases with portal pressure. We further hypothesized that the rate of stiffness change with pressure would be larger in liver tissue treated to simulate the stiffening effects of fibrosis. In agreement with our hypothesis, the formalin-treated livers were stiffer than the untreated livers, and in both groups the liver stiffness increased with portal venous pressure. The rate of stiffness change with portal pressure was significantly greater after formalin treatment. In this study, we have developed an ex vivo liver model incorporating portal venous pressure variations and observed significant changes in liver stiffness due to portal pressure. This model could be useful for understanding and investigating the changes in the static and dynamic components of liver stiffness.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660924/pdf
Ending Page	95
Page Count	4
Starting Page	92
ISSN	0730725X
e-ISSN	18735894
DOI	10.1016/j.mri.2017.08.009
Journal	Magnetic resonance imaging
Volume Number	44
Language	English
Publisher	Elsevier BV
Publisher Date	2017-12-01
Access Restriction	Open
Subject Keyword	Journal: Magnetic resonance imaging Ex Vivo Magnetic Resonance Elastography Porcine Model Portal Hypertension
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging Biophysics Biomedical Engineering

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