NDLI: Selective chiral inhibitors of 5-lipoxygenase with anti-inflammatory activity

Content Provider	Scilit
Author	McMillan, R. M. Girodeau, J. -M. Foster, S. J.
Copyright Year	1990
Description	Journal: British Journal of Pharmacology The studies described here, using enantiomers of an optically-active methoxy alkyl thiazole ICI216800 (1-methoxy-6-(naphth-2-yl-methoxy)-1-(thiazol-2-yl)indane), provide unequivocal evidence for a specific, chiral interaction with 5-lipoxygenase. In accordance with their biochemical efficacy these compounds also demonstrate enantio-specific anti-inflammatory activity in a leukotriene-mediated model of inflammation. This is the first class of compounds for which 5-lipoxygenase inhibition and anti-inflammatory activity have been shown to be mediated via a specific chiral interaction.
Related Links	https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1990.tb14111.x
Ending Page	503
Page Count	3
Starting Page	501
e-ISSN	14765381
DOI	10.1111/j.1476-5381.1990.tb14111.x
Journal	British Journal of Pharmacology
Issue Number	3
Volume Number	101
Language	English
Publisher	Wiley-Blackwell
Publisher Date	1990-11-01
Access Restriction	Open
Subject Keyword	Journal: British Journal of Pharmacology Medicinal Chemistry Anti Inflammatory Activity
Content Type	Text
Resource Type	Article

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Selective chiral inhibitors of 5-lipoxygenase with anti-inflammatory activity