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Synthesis, Antioxidant and Anti-inflammatory Activity of Novel Arylacetic and Aryl-hydroxamic Acids

Content Provider	Scilit
Author	Pontiki, Eleni A. Hadjipavlou-Litina, Dimitra J.
Copyright Year	2003
Description	Four new aryl-acetic acids and the corresponding hydroxamic acids were synthesized. These compounds showed interesting interaction with the free radical 1,1-diphenyl-2-picryl-hydrazyl (DPPH), scavenging activity on ·OH, inhibition of soybean lipoxygenase and a significant inhibition of carrageenin induced paw edema in rats (44.1−70.9 %) at a concentration of 0.01 mmol/100g. Synthese sowie antioxydierende und anti-inflammatorische Aktivität neuer Arylessigsäuren und Hydroxaminsäuren In der vorliegenden Arbeit werden neue Arylessigsäuren und Hydroxaminsäuren dargestellt. Die Verbindungen zeigten Wechselwirkung mit dem stabilen freien Radikal 1,1-Diphenyl-2-picrylhydrazyl (DPPH), Hydroxylradikalfänger-Aktivität sowie Hemmwirkung auf die Lipoxygenase der Sojabohne. Sie zeigten außerdem signifikante Hemmwirkung bei Entzündungen (44.1−70.9 %).
Related Links	http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0031-1299829.pdf
Ending Page	785
Page Count	6
Starting Page	780
ISSN	00044172
e-ISSN	16167066
DOI	10.1055/s-0031-1299829
Journal	Arzneimittelforschung
Issue Number	11
Volume Number	53
Language	English
Publisher	Georg Thieme Verlag KG
Publisher Date	2003-11-01
Access Restriction	Open
Subject Keyword	Journal: Arzneimittelforschung Medicinal Chemistry Organic Chemistry Anti-inflammatories Anti-inflammatory Activity Antioxidant Activity Lipoxygenase Inhibitors
Content Type	Text
Resource Type	Article
Subject	Drug Discovery

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